Rationale: Secure isotope analyses are used on valuable archaeological and paleontological supplies regardless of their damaging nature, as a result of the data gained by these strategies on e.g. feeding habits, migration and well being of people, can not in any other case be obtained. We approached this subject by devising a brand new sequential extraction scheme aimed to supply a number of (O, C, N) isotope proxies from small pattern quantities.
Strategies: The brand new extraction scheme consists of dissolution of the bone in dilute HNO3 adopted by separate remedies of the collagenous and phosphate fractions. The collagen fraction is handled additional adopting the strategies offered in literature for collagen extraction, modified to accommodate small pattern sizes. The phosphate containing fraction is purified from natural contaminants by H2 O2 and the phosphate is precipitated as Ag3 PO4 following strategies offered in literature. The usage of HF as demineralization agent can be examined.
Outcomes: Beginning quantity of ~2 mg was sufficient to supply sufficient materials for evaluation of the collagen C and N isotope compositions and bone phosphate O isotope composition. We present that the isotopic information obtained from the sequential extraction scheme are comparable with the isotopic composition measured following standard methodologies which are often primarily based on 100-500 mg pattern sizes.
Conclusions: The brand new sequential extraction scheme combines the preparation for secure isotope evaluation of bone mineral and natural phases, thus minimizing the pattern quantities wanted and harm brought about on a pattern piece. The tactic might enable evaluation of skeletal samples beforehand excluded from isotope evaluation as a consequence of materials limitations.
Counterbalancing the time-dependent impact on the human mitochondrial DNA molecular clock
Background: The molecular clock is a vital genetic device for estimating evolutionary timescales. Nevertheless, the detection of a time-dependent impact on substitution fee estimates complicates its software. It has been urged that demographic processes could possibly be the primary reason for this confounding impact. Within the current research, I suggest a brand new algorithm for estimating the coalescent age of phylogenetically associated sequences, considering the noticed time-dependent impact on the molecular fee detected by others.
Outcomes: By making use of this technique to actual human mitochondrial DNA bushes with shallow and deep topologies, I obtained considerably older molecular ages for the primary occasions of human evolution than had been beforehand estimated. These ages are in shut settlement with the latest archaeological and paleontological information favoring the emergence of early anatomically trendy people in Africa 315 ± 34 thousand years in the past (kya) and the presence of current trendy people outdoors of Africa as early as 174 ± 48 thousand years in the past. Moreover, throughout the implementation course of, I demonstrated that in a inhabitants with fluctuating sizes, the chance of fixation of a brand new impartial mutant relies on the efficient inhabitants measurement, which is in higher accordance with the truth that below the impartial principle of molecular evolution, the destiny of a molecular mutation is especially decided by random drift.
Conclusions: I recommend that the demographic historical past of populations has a extra decisive impact than purifying choice and/or mutational saturation on the time-dependent impact noticed for the substitution fee, and I suggest a brand new technique that corrects for this impact.
Internal morphological and metric characterization of the molar stays from the Montmaurin-La Area of interest mandible: The Neanderthal sign
Right here, we current a metric and morphological research of the molar stays from the Montmaurin-La Area of interest mandible by way of microcomputed tomography. In line with the final evaluation, primarily based on the mixture of geomorphological and paleontological information, the extent bearing this human mandible most likely corresponds to the marine isotope phases (MIS) 7. These information place the Montmaurin-La Area of interest in a chronologically intermediate place between the Neanderthals and the Center Pleistocene fossils (e.g., Sima de los Huesos, la Caune de l’Arago). A current research has revealed that whereas the mandible is extra carefully associated to the Early and Center Pleistocene African and Eurasian populations, the morphology of the outer enamel surfaces of its molars is typical of the Neanderthal linage
A1BG siRNA |
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20-abx906223 | Abbexa |
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A1BG siRNA (Rat) |
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MBS8216443-15nmol | MyBiosource | 15nmol | 405 EUR |
A1BG siRNA (Rat) |
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MBS8216443-30nmol | MyBiosource | 30nmol | 565 EUR |
A1BG siRNA (Rat) |
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MBS8216443-5x30nmol | MyBiosource | 5x30nmol | 2450 EUR |
A1BG siRNA (Human) |
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MBS8221516-15nmol | MyBiosource | 15nmol | 405 EUR |
A1BG siRNA (Human) |
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MBS8221516-30nmol | MyBiosource | 30nmol | 565 EUR |
A1BG siRNA (Human) |
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MBS8221516-5x30nmol | MyBiosource | 5x30nmol | 2450 EUR |
A1BG siRNA (Mouse) |
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MBS8226411-15nmol | MyBiosource | 15nmol | 405 EUR |
A1BG siRNA (Mouse) |
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MBS8226411-30nmol | MyBiosource | 30nmol | 565 EUR |
A1BG siRNA (Mouse) |
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MBS8226411-5x30nmol | MyBiosource | 5x30nmol | 2450 EUR |
A1bg (Rat) - 3 unique 27mer siRNA duplexes - 2 nmol each |
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SR506426 | Origene Technologies GmbH | 2 nmol | Ask for price |
A1bg (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each |
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SR416421 | Origene Technologies GmbH | 2 nmol | Ask for price |
A1BG (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each |
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SR300001 | Origene Technologies GmbH | 2 nmol | Ask for price |
A1BG antibody |
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10R-2178 | Fitzgerald | 100 ul | 468 EUR |
Description: Mouse monoclonal A1BG antibody |
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A1BG Antibody |
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37303 | SAB | 100ul | 319 EUR |
A1BG Antibody |
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37303-100ul | SAB | 100ul | 302.4 EUR |
A1BG Antibody |
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E037303 | EnoGene | 100μg/100μl | 255 EUR |
Description: Available in various conjugation types. |
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A1BG Antibody |
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E10-30025 | EnoGene | 100μg/100μl | 225 EUR |
Description: Available in various conjugation types. |
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A1BG Antibody |
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E301533 | EnoGene | 100ug/200ul | 275 EUR |
Description: Available in various conjugation types. |
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A1BG antibody |
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70R-1579 | Fitzgerald | 100 ug | 407 EUR |
Description: Rabbit polyclonal A1BG antibody raised against the N terminal of A1BG |
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A1BG antibody |
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70R-49320 | Fitzgerald | 100 ul | 242 EUR |
Description: Purified Polyclonal A1BG antibody |
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A1BG antibody |
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70R-5403 | Fitzgerald | 50 ug | 467 EUR |
Description: Rabbit polyclonal A1BG antibody raised against the N terminal of A1BG |
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A1BG antibody |
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70R-8009 | Fitzgerald | 50 ug | 467 EUR |
Description: Affinity purified rabbit polyclonal A1BG antibody |
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A1BG Antibody |
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1-CSB-PA004674 | Cusabio |
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Description: A polyclonal antibody against A1BG. Recognizes A1BG from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/40000 |
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A1BG Antibody |
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1-CSB-PA278727 | Cusabio |
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Description: A polyclonal antibody against A1BG. Recognizes A1BG from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:1000-1:2000, WB:1:200-1:1000 |
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A1BG Antibody |
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1-CSB-PA289003 | Cusabio |
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Description: A polyclonal antibody against A1BG. Recognizes A1BG from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:1000-1:2000, WB:1:200-1:1000 |
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A1BG Antibody |
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1-CSB-PA001001GA01HU | Cusabio |
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Description: A polyclonal antibody against A1BG. Recognizes A1BG from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC |
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A1BG Antibody |
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1-CSB-PA001001LA01HU | Cusabio |
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Description: A polyclonal antibody against A1BG. Recognizes A1BG from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200 |
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A1BG Antibody |
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F50307-0.08ML | NSJ Bioreagents | 0.08 ml | 140.25 EUR |
Description: Alpha-1B-glycoprotein is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. |
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A1BG Antibody |
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F50307-0.4ML | NSJ Bioreagents | 0.4 ml | 322.15 EUR |
Description: Alpha-1B-glycoprotein is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. |
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A1BG Antibody |
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GWB-409DC4 | GenWay Biotech | 0.05 mg | Ask for price |
A1BG Antibody |
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GWB-ML687C | GenWay Biotech | 100ug | Ask for price |
A1BG Antibody |
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GWB-ML688D | GenWay Biotech | 50ug | Ask for price |
A1BG antibody |
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BF0569 | Nova Lifetech | 100ug | 355 EUR |
A1BG Antibody |
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MBS7104709-005mg | MyBiosource | 0.05mg | 190 EUR |
A1BG Antibody |
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MBS7104709-01mg | MyBiosource | 0.1mg | 270 EUR |
A1BG Antibody |
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MBS7104709-5x01mg | MyBiosource | 5x0.1mg | 1205 EUR |
A1BG Antibody |
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MBS7128314-005mL | MyBiosource | 0.05mL | 190 EUR |
A1BG Antibody |
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MBS7128314-01mL | MyBiosource | 0.1mL | 270 EUR |
A1BG Antibody |
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MBS7128314-5x01mL | MyBiosource | 5x0.1mL | 1205 EUR |
A1BG Antibody |
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MBS7128315-005mL | MyBiosource | 0.05mL | 190 EUR |
A1BG Antibody |
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MBS7128315-01mL | MyBiosource | 0.1mL | 270 EUR |
A1BG Antibody |
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MBS7128315-5x01mL | MyBiosource | 5x0.1mL | 1205 EUR |
A1BG Antibody |
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MBS7117308-005mg | MyBiosource | 0.05mg | 150 EUR |
A1BG Antibody |
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MBS7117308-01mg | MyBiosource | 0.1mg | 190 EUR |
A1BG Antibody |
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MBS7117308-5x01mg | MyBiosource | 5x0.1mg | 845 EUR |
A1BG Antibody |
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MBS9407599-01mL | MyBiosource | 0.1mL | 305 EUR |
A1BG Antibody |
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MBS9407599-5x01mL | MyBiosource | 5x0.1mL | 1230 EUR |
A1BG Antibody |
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MBS853665-01mg | MyBiosource | 0.1mg | 345 EUR |
A1BG Antibody |
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MBS853665-01mLAF405L | MyBiosource | 0.1mL(AF405L) | 565 EUR |
A1BG Antibody |
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MBS853665-01mLAF405S | MyBiosource | 0.1mL(AF405S) | 565 EUR |
A1BG Antibody |
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MBS853665-01mLAF610 | MyBiosource | 0.1mL(AF610) | 565 EUR |
A1BG Antibody |
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MBS853665-01mLAF635 | MyBiosource | 0.1mL(AF635) | 565 EUR |
A1BG Antibody |
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MBS850208-01mg | MyBiosource | 0.1mg | 305 EUR |
A1BG Antibody |
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MBS850208-01mLAF405L | MyBiosource | 0.1mL(AF405L) | 565 EUR |
A1BG Antibody |
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MBS850208-01mLAF405S | MyBiosource | 0.1mL(AF405S) | 565 EUR |
A1BG Antibody |
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MBS850208-01mLAF610 | MyBiosource | 0.1mL(AF610) | 565 EUR |
A1BG Antibody |
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MBS850208-01mLAF635 | MyBiosource | 0.1mL(AF635) | 565 EUR |
A1BG antibody |
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MBS830587-01mL | MyBiosource | 0.1mL | 810 EUR |
A1BG antibody |
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MBS830587-5x01mL | MyBiosource | 5x0.1mL | 3505 EUR |
A1BG Antibody |
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MBS5313940-01mL | MyBiosource | 0.1mL | 470 EUR |
A1BG Antibody |
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MBS5313940-5x01mL | MyBiosource | 5x0.1mL | 1955 EUR |
A1BG Antibody |
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C14418-100ul | Assay Biotech | 100μl | 217 EUR |
Description: A1BG Rabbit Polyclonal Antibody |
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A1BG Antibody |
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C14418-50ul | Assay Biotech | 50μl | 143.5 EUR |
Description: A1BG Rabbit Polyclonal Antibody |
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A1BG Antibody |
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BF0569-100ul | Affinity Biosciences | 100ul | 210 EUR |
Description: WB,IHC,ELISA |
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A1BG Antibody |
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BF0569-200ul | Affinity Biosciences | 200ul | Ask for price |
Description: WB,IHC,ELISA |
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A1BG Antibody |
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BF0569-50ul | Affinity Biosciences | 50ul | 150 EUR |
Description: WB,IHC,ELISA |
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A1BG (untagged)-Human alpha-1-B glycoprotein (A1BG) |
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SC313722 | Origene Technologies GmbH | 10 µg | Ask for price |
A1BG (GFP-tagged) - Human alpha-1-B glycoprotein (A1BG) |
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RG221406 | Origene Technologies GmbH | 10 µg | Ask for price |
A1bg (untagged) - Mouse alpha-1-B glycoprotein (A1bg), (10ug) |
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MC217347 | Origene Technologies GmbH | 10 µg | Ask for price |
A1BG Mouse mAb |
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E2220398 | EnoGene | 100ul | 225 EUR |
Description: Available in various conjugation types. |
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A1BG Mouse mAb |
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MBS8538608-01mL | MyBiosource | 0.1mL | 305 EUR |
A1BG Mouse mAb |
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MBS8538608-01mLAF405L | MyBiosource | 0.1mL(AF405L) | 565 EUR |
A1BG Mouse mAb |
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MBS8538608-01mLAF405S | MyBiosource | 0.1mL(AF405S) | 565 EUR |
A1BG Mouse mAb |
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MBS8538608-01mLAF610 | MyBiosource | 0.1mL(AF610) | 565 EUR |
A1BG Mouse mAb |
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MBS8538608-01mLAF635 | MyBiosource | 0.1mL(AF635) | 565 EUR |
A1BG Rabbit pAb |
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A11583-100ul | Abclonal | 100 ul | 369.6 EUR |
A1BG Rabbit pAb |
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A11583-200ul | Abclonal | 200 ul | 550.8 EUR |
A1BG Rabbit pAb |
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A11583-20ul | Abclonal | 20 ul | 219.6 EUR |
A1BG Rabbit pAb |
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A11583-50ul | Abclonal | 50 ul | 267.6 EUR |
A1BG Rabbit pAb |
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E2251407 | EnoGene | 100ul | 225 EUR |
Description: Available in various conjugation types. |
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A1BG Rabbit pAb |
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E2511583 | EnoGene | 100ul | 225 EUR |
Description: Available in various conjugation types. |
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A1BG Rabbit pAb |
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A15015-100ul | Abclonal | 100 ul | 369.6 EUR |
A1BG Rabbit pAb |
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A15015-200ul | Abclonal | 200 ul | 550.8 EUR |
A1BG Rabbit pAb |
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A15015-20ul | Abclonal | 20 ul | 219.6 EUR |
A1BG Rabbit pAb |
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A15015-50ul | Abclonal | 50 ul | 267.6 EUR |
A1BG Rabbit pAb |
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MBS8548567-01mL | MyBiosource | 0.1mL | 305 EUR |
A1BG Rabbit pAb |
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MBS8548567-01mLAF405L | MyBiosource | 0.1mL(AF405L) | 565 EUR |
A1BG Rabbit pAb |
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MBS8548567-01mLAF405S | MyBiosource | 0.1mL(AF405S) | 565 EUR |
A1BG Rabbit pAb |
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MBS8548567-01mLAF610 | MyBiosource | 0.1mL(AF610) | 565 EUR |
A1BG Rabbit pAb |
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MBS8548567-01mLAF635 | MyBiosource | 0.1mL(AF635) | 565 EUR |
A1BG Rabbit pAb |
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MBS8540020-01mL | MyBiosource | 0.1mL | 305 EUR |
A1BG Rabbit pAb |
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MBS8540020-01mLAF405L | MyBiosource | 0.1mL(AF405L) | 565 EUR |
A1BG Rabbit pAb |
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MBS8540020-01mLAF405S | MyBiosource | 0.1mL(AF405S) | 565 EUR |
A1BG Rabbit pAb |
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MBS8540020-01mLAF610 | MyBiosource | 0.1mL(AF610) | 565 EUR |
A1BG Rabbit pAb |
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MBS8540020-01mLAF635 | MyBiosource | 0.1mL(AF635) | 565 EUR |
A1BG Rabbit pAb |
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A8969 | Abclonal | 100μL | 88.56 EUR |
A1BG Rabbit pAb |
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A11583 | Abclonal | 50μL | 70.85 EUR |
A1BG Rabbit pAb |
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A15015 | Abclonal | 50μL | 262.15 EUR |
anti- A1BG antibody |
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FNab00012 | FN Test | 100µg | 606.3 EUR |
Description: Antibody raised against A1BG |
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A1BG Antibody (Center) |
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MBS9203583-008mL | MyBiosource | 0.08mL | 210 EUR |
A1BG Antibody (Center) |
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MBS9203583-04mL | MyBiosource | 0.4mL | 430 EUR |
A1BG Antibody (Center) |
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MBS9203583-5x04mL | MyBiosource | 5x0.4mL | 1910 EUR |
A1bg (GFP-tagged) - Mouse alpha-1-B glycoprotein (A1bg), (10ug) |
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MG216771 | Origene Technologies GmbH | 10 µg | Ask for price |
A1BG Blocking Peptide |
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33R-4184 | Fitzgerald | 100 ug | 119 EUR |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of A1BG antibody, catalog no. 70R-1579 |
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A1BG Blocking Peptide |
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33R-7870 | Fitzgerald | 100 ug | 119 EUR |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of A1BG antibody, catalog no. 70R-8009 |
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A1BG Blocking Peptide |
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BF0569-BP | Affbiotech | 1mg | 234 EUR |
A1BG Blocking Peptide |
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MBS9620183-1mg | MyBiosource | 1mg | 380 EUR |
A1BG Blocking Peptide |
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MBS9620183-5x1mg | MyBiosource | 5x1mg | 1650 EUR |
A1bg (Myc-DDK-tagged) - Mouse alpha-1-B glycoprotein (A1bg) |
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MR216771 | Origene Technologies GmbH | 10 µg | Ask for price |
A1BG (Myc-DDK-tagged)-Human alpha-1-B glycoprotein (A1BG) |
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RC221406 | Origene Technologies GmbH | 10 µg | Ask for price |
A1BG, ID (A1BG, Alpha-1B-glycoprotein, Alpha-1-B glycoprotein) |
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MBS645775-02mL | MyBiosource | 0.2mL | 695 EUR |
A1BG, ID (A1BG, Alpha-1B-glycoprotein, Alpha-1-B glycoprotein) |
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MBS645775-5x02mL | MyBiosource | 5x0.2mL | 2975 EUR |
A1BG Polyclonal Antibody |
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ABP52788-003ml | Abbkine | 0.03ml | 189.6 EUR |
Description: A polyclonal antibody for detection of A1BG from Human. This A1BG antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human A1BG at AA range: 100-180 |
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A1BG Polyclonal Antibody |
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ABP52788-01ml | Abbkine | 0.1ml | 346.8 EUR |
Description: A polyclonal antibody for detection of A1BG from Human. This A1BG antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human A1BG at AA range: 100-180 |
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A1BG Polyclonal Antibody |
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ABP52788-02ml | Abbkine | 0.2ml | 496.8 EUR |
Description: A polyclonal antibody for detection of A1BG from Human. This A1BG antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human A1BG at AA range: 100-180 |
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A1BG Polyclonal Antibody |
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E20-75057 | EnoGene | 100ug | 225 EUR |
Description: Available in various conjugation types. |
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A1BG Polyclonal Antibody |
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E911583 | EnoGene | 100ul | 225 EUR |
Description: Available in various conjugation types. |
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A1BG Polyclonal Antibody |
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E98969 | EnoGene | 100ul | 225 EUR |
Description: Available in various conjugation types. |
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A1BG Polyclonal Antibody |
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E915015 | EnoGene | 100ul | 225 EUR |
Description: Available in various conjugation types. |
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Monoclonal A1BG Antibody |
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AMM02180G | Leading Biology | 0.05ml | 580.8 EUR |
Description: A Monoclonal antibody against Human A1BG. The antibodies are raised in Mouse. This antibody is applicable in WB and IHC-P, E |
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A1BG Conjugated Antibody |
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C37303 | SAB | 100ul | 476.4 EUR |
A1BG Polyclonal Antibody |
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E-AB-16125-120uL | Elabscience Biotech | 120uL | 240 EUR |
Description: Unconjugated |
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A1BG Polyclonal Antibody |
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E-AB-16125-200uL | Elabscience Biotech | 200uL | 399 EUR |
Description: Unconjugated |
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A1BG Polyclonal Antibody |
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E-AB-16125-20uL | Elabscience Biotech | 20uL | 73 EUR |
Description: Unconjugated |
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A1BG Polyclonal Antibody |
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E-AB-16125-60uL | Elabscience Biotech | 60uL | 143 EUR |
Description: Unconjugated |
|||
A1BG Monoclonal Antibody |
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BT-MCA0118-100ul | Jiaxing Korain Biotech Ltd (BT Labs) | 100ul | Ask for price |
Description: The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. |
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A1BG Monoclonal Antibody |
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BT-MCA0118-50ul | Jiaxing Korain Biotech Ltd (BT Labs) | 50ul | Ask for price |
Description: The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. |
|||
A1BG Polyclonal Antibody |
|||
E44H06499 | EnoGene | 100ul | 255 EUR |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
|||
A1BG Polyclonal Antibody |
|||
E-AB-66384-120uL | Elabscience Biotech | 120uL | 320 EUR |
Description: Unconjugated |
|||
A1BG Polyclonal Antibody |
|||
E-AB-66384-200uL | Elabscience Biotech | 200uL | 530 EUR |
Description: Unconjugated |
|||
A1BG Polyclonal Antibody |
|||
E-AB-66384-60uL | Elabscience Biotech | 60uL | 200 EUR |
Description: Unconjugated |
. The info offered listed below are according to this discovering as a result of the morphology of the enamel-dentine junction of the molars is just like that of Neanderthals, whereas absolutely the and relative enamel thickness values (2D and 3D) are nearer to these exhibited by some Early Pleistocene hominins. Furthermore, the pulp cavity morphology and proportions are in concordance with the Neanderthal populations. Our outcomes strengthen the speculation that the settlement of Europe could possibly be the results of a number of migrations, at completely different instances, originated from a standard supply inhabitants. Thus, the variability within the European Center Pleistocene populations (e.g., Montmaurin, Sima de los Huesos, Arago, Mala Balanica) might point out completely different migrations at completely different instances and/or inhabitants fragmentation, with out excluding the doable hybridization between residents and new settlers.